AMP-Activated Protein Kinase Alpha-2 (AMPK Alpha-2) and Its Potential as a Drug Target: A Review

Target Name: AMP-activated protein kinase alpha2beta1gamma2

NCBI ID: P38824

Other Name(s): AMPK alpha2beta1gamma2

AMP-Activated Protein Kinase Alpha-2 (AMPK Alpha-2) and Its Potential as a Drug Target: A Review

AMP-activated protein kinase (AMPK) is a key protein that plays a crucial role in regulating cellular processes, including energy metabolism, DNA damage repair, and cell survival. AMP-activated protein kinase alpha-2 (AMPK alpha-2) is a subunit of theAMP-activated protein kinase (AMPK) enzyme, which is critical for the regulation of cellular processes. In this article, we will discuss the AMP-activated protein kinase alpha-2 (AMPK alpha-2) as a drug target and its potential in the development of new therapeutic approaches.

AMPK alpha-2: Structural and Functional Characterization

AMPK alpha-2 is a 21-kDa protein that is expressed in various tissues, including muscle, heart, and brain. It is a key subunit of theAMPK enzyme, which is composed of four subunits: alpha-2, alpha-3, beta, and gamma. The alpha-2 subunit is responsible for activating the AMP-associated protein kinase (APPK) and is the target of many therapeutic approaches.

AMPK alpha-2 is characterized by several unique features, including a 21-kDa protein that contains a catalytic active site, a regulatory N-terminus, and a C-terminus that is involved in protein-protein interactions. The alpha-2 subunit has a unique ATP-binding site that is distinct from otherAMPK subunits. Additionally, the alpha-2 subunit has a distinct subcellular localization pattern, which is characterized by a higher level of expression in muscle than in other tissues.

AMPK alpha-2 is involved in various cellular processes, including metabolism, cell survival, and stress response. It is a key regulator of the AMP-associated protein kinase (APPK), which is involved in the regulation of protein stability, DNA repair, and cell survival. In addition, AMP-activated protein kinase alpha-2 is involved in the regulation of cellular metabolism, including the regulation of glucose and lipid metabolism.

AMPK alpha-2 as a Drug Target

AMPK alpha-2 is a potential drug target due to its involvement in various cellular processes that can be targeted by small molecules. Several studies have shown that small molecules can inhibit the activity of AMP-activated protein kinase alpha-2 and enhance its stability. These small molecules include inhibitors of the kinase activity, such as compound A, which is a potent inhibitor of the AMP-associated protein kinase (APPK).

In addition to inhibitors of the kinase activity, small molecules can also enhance the stability of AMP-activated protein kinase alpha-2 by modifying its structure. For example, small molecules can increase the level of disulfide bonds in the protein, which can enhance its stability.

AMPK alpha-2 as a Biomarker

AMP-activated protein kinase alpha-2 (AMPK alpha-2) is also a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. The deregulation of AMP-activated protein kinase alpha-2 has been observed in various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

AMP-activated protein kinase alpha-2 has been shown to be involved in the regulation of cellular processes that are associated with the development and progression of these diseases. For example, AMP-activated protein kinase alpha-2 has been shown to be involved in the regulation of cancer cell survival and angiogenesis. In addition, the deregulation of AMP-activated protein kinase alpha-2 has

Protein Name: AMP-activated Protein Kinase Alpha2beta1gamma2

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